Source: melting Maintainer: Debian Med Packaging Team Uploaders: Charles Plessy , Andreas Tille Section: science Priority: optional Build-Depends: debhelper-compat (= 13), javahelper, ant, ant-optional, default-jdk, Standards-Version: 4.5.1 Vcs-Browser: https://salsa.debian.org/med-team/melting Vcs-Git: https://salsa.debian.org/med-team/melting.git Homepage: https://www.ebi.ac.uk/compneur-srv/melting/ Rules-Requires-Root: no Package: melting Architecture: all Depends: ${java:Depends}, ${misc:Depends}, default-jre | java-runtime, java-wrappers Suggests: melting-gui Description: compute the melting temperature of nucleic acid duplex This program computes, for a nucleic acid duplex, the enthalpy, the entropy and the melting temperature of the helix-coil transitions. Three types of hybridisation are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program first computes the hybridisation enthalpy and entropy from the elementary parameters of each Crick's pair by the nearest-neighbor method. Then the melting temperature is computed. The set of thermodynamic parameters can be easily changed, for instance following an experimental breakthrough.