Source: r-bioc-multtest Section: gnu-r Priority: optional Maintainer: Debian R Packages Maintainers Uploaders: Andreas Tille Vcs-Browser: https://salsa.debian.org/r-pkg-team/r-bioc-multtest Vcs-Git: https://salsa.debian.org/r-pkg-team/r-bioc-multtest.git Homepage: https://bioconductor.org/packages/multtest/ Standards-Version: 4.6.2 Rules-Requires-Root: no Build-Depends: debhelper-compat (= 13), dh-r, r-base-dev, r-bioc-biocgenerics, r-bioc-biobase, r-cran-survival, r-cran-mass Testsuite: autopkgtest-pkg-r Package: r-bioc-multtest Architecture: any Depends: ${R:Depends}, ${shlibs:Depends}, ${misc:Depends} Recommends: ${R:Recommends} Suggests: ${R:Suggests} Description: Bioconductor resampling-based multiple hypothesis testing Non-parametric bootstrap and permutation resampling-based multiple testing procedures (including empirical Bayes methods) for controlling the family-wise error rate (FWER), generalized family-wise error rate (gFWER), tail probability of the proportion of false positives (TPPFP), and false discovery rate (FDR). Several choices of bootstrap-based null distribution are implemented (centered, centered and scaled, quantile-transformed). Single-step and step-wise methods are available. Tests based on a variety of t- and F-statistics (including t-statistics based on regression parameters from linear and survival models as well as those based on correlation parameters) are included. When probing hypotheses with t-statistics, users may also select a potentially faster null distribution which is multivariate normal with mean zero and variance covariance matrix derived from the vector influence function. Results are reported in terms of adjusted p-values, confidence regions and test statistic cutoffs. The procedures are directly applicable to identifying differentially expressed genes in DNA microarray experiments.