Source: r-bioc-pfamanalyzer Standards-Version: 4.7.4 Maintainer: Debian R Packages Maintainers Uploaders: Andreas Tille , Section: gnu-r Testsuite: autopkgtest-pkg-r Build-Depends: debhelper-compat (= 14), dh-r, r-base-dev, r-cran-readr, r-cran-stringr, r-cran-dplyr, r-cran-tibble, r-cran-magrittr, r-pkg-team-core-architecture, Vcs-Browser: https://salsa.debian.org/r-pkg-team/r-bioc-pfamanalyzer Vcs-Git: https://salsa.debian.org/r-pkg-team/r-bioc-pfamanalyzer.git Homepage: https://bioconductor.org/packages/pfamAnalyzeR/ Package: r-bioc-pfamanalyzer Architecture: all Depends: ${R:Depends}, ${misc:Depends}, r-pkg-team-core-architecture, Recommends: ${R:Recommends}, Suggests: ${R:Suggests}, Description: Identification of domain isotypes in pfam data Protein domains is one of the most import annoation of proteins we have with the Pfam database/tool being (by far) the most used tool. This R package enables the user to read the pfam prediction from both webserver and stand-alone runs into R. We have recently shown most human protein domains exist as multiple distinct variants termed domain isotypes. Different domain isotypes are used in a cell, tissue, and disease-specific manner. Accordingly, we find that domain isotypes, compared to each other, modulate, or abolish the functionality of a protein domain. This R package enables the identification and classification of such domain isotypes from Pfam data.